Developing deodorising ingredients based on an ex vivo sweat model

Developing deodorising ingredients based on an ex vivo sweat model

Back in 2018, Symrise’s Director of Microbiology Research, Steffen Nordzieke, and his team were tasked with developing a new and sustainable deodorising ingredient from renewable sources that also didn’t cause any negative effects on the underarm microbiome.   

Nordzieke said they started by screening green and sustainable materials and that the development was based on single species. “There are many things to consider, efficacy is only one point,” ​he shared. “We start with efficacy and if that’s good then we move on the assess other factors. Then after that’s all done, we will finally start an in vivo study.”

“We now know that these bacteria affect each other, so the process is more complex than it once was,” he​ explained. “For example, some bacteria are fine on your skin but under your armpit is considered a ‘bad guy’ as it causes an odour.

Starting with an ex vivo model

To help initially assess ingredients, the team developed an ex vivo​ model.

“We took sweat from volunteers and incubated the sweat for 48 hours with and without our ingredients, ​shared Nordzieke. “Then we had an ‘odour panel’ to give a verdict.”

“We looked at whether our model could reflect real life,” he continued. “We saw that the typical sweat odour developed in the small tubes so then we could start our identification process on materials. We put our ingredients in there to incubate to see if it was able to reduce the odour.“

The team also wanted to better understand the full impact the ingredient was having on the microbiome while it was acting on the sweat.  

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