Glycation, a biochemical process that accelerates skin aging, is gaining increased attention in dermatology and aesthetic medicine. While environmental factors such as UV radiation, pollution, and blue light are widely recognized as contributors to aging, glycation remains an underappreciated but significant cause of visible skin deterioration.
A natural process worsened by poor diet, environmental factors, and aging, glycation “involves sugars binding to proteins, like collagen and elastin, and forming harmful substances called Advanced Glycation Endproducts (AGEs)” which stiffen proteins, Dr. Vivian Bucay of the Bucay Center for Dermatology & Aesthetics told CosmeticsDesign.
This results in visible signs of aging that compromise the skin’s youthful appearance, such as dullness, uneven texture, and redness, she said.
Glycated collagen accumulates at an estimated rate of 3.7% per year, making intervention an appealing option to beauty-from-within consumers, she added.
BioRewind & glycation management
One emerging solution for addressing glycation is skinbetter science’s BioRewind, a recently launched dietary supplement designed to mitigate the formation of AGEs. A key component of BioRewind’s formulation is its proprietary CORExtract biotechnology, which features an optimized rosemary leaf extract.
Co-Factor Optimized Rosemary Extract, or CORExtract, contains “natural rosmarinic acid and other synergistic antioxidants, preserved and optimized through a multi-sequence extraction process,” said Dr. Bucay.
She noted that this bio-optimized extract has demonstrated greater efficacy in reversing glycation than rosmarinic acid alone, and the formula is also free from gluten, colorants, and dyes.
Complementing topical skin care regimens
Consumer interest in ingestible beauty products continues to rise, reflecting a shift toward a more holistic approach to skin care. Dietary supplements like BioRewind provide a complementary approach to enhancing results for individuals already following topical skin care routines.
“Consumers are looking at a more holistic view of beauty,” Dr. Bucay noted. “Instead of chasing lines and wrinkles, they are interested in beauty from the inside out,” she added, and as a result, “now more than ever, my colleagues and I are talking to our patients about including supplements as part of their routine.”
Research and clinical findings
Further data on BioRewind’s efficacy will be featured in the March issue of the Journal of Clinical and Aesthetic Dermatology. Dr. Bucay highlighted key takeaways from the research, particularly the 12-week clinical study results.
“There are several details worth noting, but the most impactful were 12-week findings that showed a 17% improvement in global skin quality compared to baseline measurements, as well as significant improvements in rough texture and dullness,” she illustrated.
As research into glycation and its effects on skin health continues, the role of ingestible solutions like BioRewind will likely expand, offering new opportunities for skin care professionals and manufacturers alike.
“The launch of BioRewind marks a significant milestone for skinbetter science and medical-grade skin care,” said Jonah Shacknai, CEO of skinbetter science, in a press statement.
“With BioRewind, we are introducing a new approach to counteract skin aging by addressing glycation, a lesser-known but extremely critical factor in the skin aging process, and “we are confident this innovation will redefine how we think about skin health,” he concluded.
